org.simBio.bio.matsuoka_et_al_2003.molecule.enzyme
Class CrossBridgeNL

java.lang.Object
  org.simBio.core.Component
      org.simBio.core.Parameter
          org.simBio.core.Composite
              org.simBio.core.Reactor
                  org.simBio.bio.matsuoka_et_al_2003.molecule.enzyme.CrossBridgeNL

All Implemented Interfaces:

Node

Direct Known Subclasses:

IsometricContraction, IsotonicContraction

public abstract class CrossBridgeNL
extends Reactor

Cross bridge kinetics of Cardiac Muscle Model by Negroni and Lascano.

Version:

$Log: CrossBridgeNL.java,v $ Revision 1.1 2005/11/01 06:32:40 mikaelwing First version of simBio hosted on sourceforge, version 0.3 Revision 1.1 2005/09/12 04:57:34 sarai rearrenge folder structure as a Maven style Revision 1.4 2005/08/29 02:02:49 sarai dX/dT^2 is the same as in the Matsuoka et al, 2004

Author:

Nobuaki Sarai, modified by Kim

See Also:

Negroni JA and Lascano EC, A cardiac muscle model relating sarcomere dynamics to calcium kinetics. J Mol Cell Cardiol 28: 915-929, 1996., explanation (WORD doc)

Field Summary

Node	forceCB
protected double	ForceEcomp
Node	forceExt
protected double	forceFactor
Node	h
Node	halfsarcomerelength
Node	InextensibleLength
protected double	KForceEC
protected double	KForceLinearEc
protected double	NewCBF
protected double	optimumHSL
TroponinNL	troponin
protected double	ZeroForceEL

Fields inherited from class org.simBio.core.Parameter

value

Constructor Summary

CrossBridgeNL()

Method Summary

protected void	calculate(double t) calculate the rate of change in the cross bridge length, dX/dt
double	getCBfactor()
double	getEffectiveFraction()

Methods inherited from class org.simBio.core.Composite

accept, getLink, getNode, getNodesIterator, getNodesSize

Methods inherited from class org.simBio.core.Parameter

addValue, getValue, getValueString, prepare, setInitializer, setValue, setValueString, setValueToField

Methods inherited from class org.simBio.core.Component

addDydt, end, getIndent, getIndentedShortName, getName, getName, getParent, getRoot, getShortName, getUnits, isNamed, isPrefixed, logIndented, quit, setLinks

Methods inherited from class java.lang.Object

clone, equals, finalize, getClass, hashCode, notify, notifyAll, toString, wait, wait, wait

Methods inherited from interface org.simBio.core.Node

addDydt, addValue, getValue, setValue

Field Detail

forceExt

public Node forceExt

forceCB

public Node forceCB

halfsarcomerelength

public Node halfsarcomerelength

NewCBF

protected double NewCBF

optimumHSL

protected double optimumHSL

KForceEC

protected double KForceEC

ZeroForceEL

protected double ZeroForceEL

KForceLinearEc

protected double KForceLinearEc

forceFactor

protected double forceFactor

ForceEcomp

protected double ForceEcomp

h

public Node h

troponin

public TroponinNL troponin

InextensibleLength

public Node InextensibleLength

Constructor Detail

CrossBridgeNL

public CrossBridgeNL()

Method Detail

getCBfactor

public double getCBfactor()

Returns:

dydtCBL²

getEffectiveFraction

public double getEffectiveFraction()

Returns:

-20(hSL-optimumHSL)²

calculate

protected void calculate(double t)

calculate the rate of change in the cross bridge length, dX/dt

Specified by:

calculate in class Reactor

Parameters:

t - elapsed time (ms)