org.simBio.bio.terashima_et_al_2006.current.carrier
Class NKCC

java.lang.Object
  extended by org.simBio.core.Component
      extended by org.simBio.core.Parameter
          extended by org.simBio.core.Composite
              extended by org.simBio.core.Reactor
                  extended by org.simBio.bio.matsuoka_et_al_2003.current.MembraneTransporter
                      extended by org.simBio.bio.terashima_et_al_2006.current.MembraneTransporter
                          extended by org.simBio.bio.terashima_et_al_2006.current.carrier.NKCC
All Implemented Interfaces:
Node

public class NKCC
extends MembraneTransporter

Flux via Na+-K+-2Cl- cotransporter [amol/msec]. x1 for Na+ and K+, x2 for Cl-.

Version:
$Id: NKCC.java,v 1.2 2007/10/18 07:03:03 nsarai Exp $
Author:
Keisuke Terashima
See Also:
NKCC.ja.doc (Japanese, WORD doc) NKCC.xml Lytle et al, 1998 Ramasamy et al, 2001 Benjamin and Johnson, 1997

Field Summary
 Node ClFlux
          Cl- current carried by NKCC1 [pA]
 Node Cli
          concentration of intracellular Cl- [mM]
 Node Clo
          concentration of extracellular Cl- [mM]
 double F
          Faraday constant.
 double kbEmpty
          rate constant for the reaction pE1->pE2 [msec-1]
 double kbFull
          rate constant for the reaction pE2NaClKCl->pE1NaClKCl [msec-1]
 double KCl
          binding constant for Cl- [mM-1]
 double kfEmpty
          rate constant for the reaction pE2->pE1 [msec-1]
 double kfFull
          rate constant for the reaction pE1NaClKCl->pE2NaClKCl [msec-1]
 Node Ki
          concentration of intracellular K+ [mM]
 double KK
          binding constant for K+ [mM-1]
 double KNa
          binding constant for Na+ [mM-1]
 Node Ko
          concentration of extracellular K+ [mM]
 Node Nai
          concentration of intracellular Na+ [mM]
 Node Nao
          concentration of extracellular Na+ [mM]
 Node P
          factor to define the maximum flux via NKCC1 [amol]
 Node pE1S
          probability of pE1S
 
Fields inherited from class org.simBio.bio.terashima_et_al_2006.current.MembraneTransporter
cCl, CCl, currentCl
 
Fields inherited from class org.simBio.bio.matsuoka_et_al_2003.current.MembraneTransporter
cCa, CCa, cK, CK, cNa, CNa, current, currentCa, currentK, currentNa, total
 
Fields inherited from class org.simBio.core.Parameter
value
 
Constructor Summary
NKCC()
           
 
Method Summary
protected  void calculate(double t)
          add Cl current to Compartment.
 
Methods inherited from class org.simBio.bio.matsuoka_et_al_2003.current.MembraneTransporter
prepare
 
Methods inherited from class org.simBio.core.Composite
accept, getLink, getNode, getNodesIterator, getNodesSize
 
Methods inherited from class org.simBio.core.Parameter
addValue, getValue, getValueString, setInitializer, setValue, setValueString, setValueToField
 
Methods inherited from class org.simBio.core.Component
addDydt, end, getIndent, getIndentedShortName, getName, getName, getParent, getRoot, getShortName, getUnits, isNamed, isPrefixed, logIndented, quit, setLinks
 
Methods inherited from class java.lang.Object
clone, equals, finalize, getClass, hashCode, notify, notifyAll, toString, wait, wait, wait
 
Methods inherited from interface org.simBio.core.Node
addDydt, addValue, getValue, setValue
 

Field Detail

Nai

public Node Nai
concentration of intracellular Na+ [mM]


Ki

public Node Ki
concentration of intracellular K+ [mM]


Cli

public Node Cli
concentration of intracellular Cl- [mM]


Nao

public Node Nao
concentration of extracellular Na+ [mM]


Ko

public Node Ko
concentration of extracellular K+ [mM]


Clo

public Node Clo
concentration of extracellular Cl- [mM]


KNa

public double KNa
binding constant for Na+ [mM-1]


KCl

public double KCl
binding constant for Cl- [mM-1]


KK

public double KK
binding constant for K+ [mM-1]


kfFull

public double kfFull
rate constant for the reaction pE1NaClKCl->pE2NaClKCl [msec-1]


kbFull

public double kbFull
rate constant for the reaction pE2NaClKCl->pE1NaClKCl [msec-1]


kfEmpty

public double kfEmpty
rate constant for the reaction pE2->pE1 [msec-1]


kbEmpty

public double kbEmpty
rate constant for the reaction pE1->pE2 [msec-1]


pE1S

public Node pE1S
probability of pE1S


P

public Node P
factor to define the maximum flux via NKCC1 [amol]


F

public double F
Faraday constant. default value is 96.4867 [C/mmol]


ClFlux

public Node ClFlux
Cl- current carried by NKCC1 [pA]

Constructor Detail

NKCC

public NKCC()
Method Detail

calculate

protected void calculate(double t)
Description copied from class: MembraneTransporter
add Cl current to Compartment.

Overrides:
calculate in class MembraneTransporter
Parameters:
t - time


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