org.simBio.bio.takeuchi_et_al_2006.current
Class PMCA

java.lang.Object
  org.simBio.core.Component
      org.simBio.core.Parameter
          org.simBio.core.Composite
              org.simBio.core.Reactor
                  org.simBio.bio.matsuoka_et_al_2003.current.MembraneTransporter
                      org.simBio.bio.terashima_et_al_2006.current.MembraneTransporter
                          org.simBio.bio.takeuchi_et_al_2006.current.PMCA

All Implemented Interfaces:

Node

public class PMCA
extends MembraneTransporter

sarcolemmal Ca²⁺ pump. The current amplitude is adjusted so that the contribution of PMCA to total Ca extrusion is 9%, according to the report by Mackiewicz and Lewartowski, 2006.

Version:

$Id: PMCA.java,v 1.1 2006/11/17 08:08:04 atakeuchi Exp $

Author:

Ayako Takeuchi

See Also:

"Luo and Rudy, Circ Res 74: 1071-1096, 1994" "Mackiewicz and Lewartowski, J Physiol Pharmacol 57: 3-15, 2006"

Field Summary

Node	Cai concentration of intracellular Ca2+ [mM]
double	Cm membrane capacitance [pF]
double	KmCai dissociation constant for Ca2+ [mM -1 ]
Node	permeabilityCa factor to define the maximum PMCA current [pA/pF]

Fields inherited from class org.simBio.bio.terashima_et_al_2006.current.MembraneTransporter

cCl, CCl, currentCl

Fields inherited from class org.simBio.bio.matsuoka_et_al_2003.current.MembraneTransporter

cCa, CCa, cK, CK, cNa, CNa, current, currentCa, currentK, currentNa, total

Fields inherited from class org.simBio.core.Parameter

value

Constructor Summary

PMCA()

Method Summary

protected void

calculate(double t) add Cl current to Compartment.

Methods inherited from class org.simBio.bio.matsuoka_et_al_2003.current.MembraneTransporter

prepare

Methods inherited from class org.simBio.core.Composite

accept, getLink, getNode, getNodesIterator, getNodesSize

Methods inherited from class org.simBio.core.Parameter

addValue, getValue, getValueString, setInitializer, setValue, setValueString, setValueToField

Methods inherited from class org.simBio.core.Component

addDydt, end, getIndent, getIndentedShortName, getName, getName, getParent, getRoot, getShortName, getUnits, isNamed, isPrefixed, logIndented, quit, setLinks

Methods inherited from class java.lang.Object

clone, equals, finalize, getClass, hashCode, notify, notifyAll, toString, wait, wait, wait

Methods inherited from interface org.simBio.core.Node

addDydt, addValue, getValue, setValue

Field Detail

Cai

public Node Cai

concentration of intracellular Ca²⁺ [mM]

KmCai

public double KmCai

dissociation constant for Ca²⁺ [mM ^-1 ]

permeabilityCa

public Node permeabilityCa

factor to define the maximum PMCA current [pA/pF]

Cm

public double Cm

membrane capacitance [pF]

Constructor Detail

PMCA

public PMCA()

Method Detail

calculate

protected void calculate(double t)

Description copied from class: MembraneTransporter

add Cl current to Compartment.

Overrides:

calculate in class MembraneTransporter

Parameters:

t - time