org.simBio.bio.matsuoka_et_al_2003.current.cf
Class ICaL

java.lang.Object
  extended by org.simBio.core.Component
      extended by org.simBio.core.Parameter
          extended by org.simBio.core.Composite
              extended by org.simBio.core.Reactor
                  extended by org.simBio.bio.matsuoka_et_al_2003.current.MembraneTransporter
                      extended by org.simBio.bio.matsuoka_et_al_2003.current.cf.CfChannel
                          extended by org.simBio.bio.matsuoka_et_al_2003.current.cf.ICaL
All Implemented Interfaces:
Node
Direct Known Subclasses:
ICaL

public class ICaL
extends CfChannel

L-type Ca channel. voltage gated, 4 state voltage gate, from Shirokov et al. 1993, 4 state Calcium gate, from Shirokov et al. 1993, ultra-slow inactivation, ATP Dependency from Noma& Shibasaki 1985 J.Physiol,363:441-462

Since:
rc20
Version:
$Log: ICaL.java,v $ Revision 1.1 2005/11/01 06:32:39 mikaelwing First version of simBio hosted on sourceforge, version 0.3 Revision 1.2 2005/10/18 03:02:23 sarai order field Revision 1.1 2005/09/12 04:57:20 sarai rearrenge folder structure as a Maven style Revision 1.3 2005/08/04 07:13:47 sarai merge with branch dev_terashima_et_al_2005 2004/12/27 05:04:30 The javadoc comments are revised
2004/12/27 01:02:18 Vshift affects only 4 state voltage gate
2004/11/22 00:29:30 introduced voltage shift, revise javadoc
Author:
Nobuaki Sarai, Kim
See Also:
Equation (16) to (41) of Table 4 in Matsuoka et al, 2003
XML example
explanation (Japanese, WORD doc)

Field Summary
 Node ATP
          intracellular ATP concentration (mM)
 Node CaDiadic
          local Ca2+ concentration near the mouth of L-type Ca channel (mM)
 Node Cai
          intracellular calcium concentration (mM)
 Node gate
          ultra-slow gate probability
 Node pAI
          AI state probability for voltage-dependent gate
 Node pAP
          AP state probability for voltage-dependent gate
 Node pC
          C state probability for calcium-dependent gate
 Node pRP
          PR state probability for voltage-dependent gate
 Node pU
          U state probability for calcium-dependent gate
 Node pUCa
          UCa state probability for calcium-dependent gate
 Node sumCa
          integration of ICaL
 Node Vm
          membrane potential (mV)
 double Vshift
          a shift of activation potential for 4 state voltage gate
 
Fields inherited from class org.simBio.bio.matsuoka_et_al_2003.current.cf.CfChannel
constantFieldCa, constantFieldK, constantFieldNa, permeabilityCa, permeabilityK, permeabilityNa, pOpen
 
Fields inherited from class org.simBio.bio.matsuoka_et_al_2003.current.MembraneTransporter
cCa, CCa, cK, CK, cNa, CNa, current, currentCa, currentK, currentNa, total
 
Fields inherited from class org.simBio.core.Parameter
value
 
Constructor Summary
ICaL()
           
 
Method Summary
protected  void calculate(double t)
          add current to Compartment.
protected  void prepare()
          construct null current
 
Methods inherited from class org.simBio.core.Composite
accept, getLink, getNode, getNodesIterator, getNodesSize
 
Methods inherited from class org.simBio.core.Parameter
addValue, getValue, getValueString, setInitializer, setValue, setValueString, setValueToField
 
Methods inherited from class org.simBio.core.Component
addDydt, end, getIndent, getIndentedShortName, getName, getName, getParent, getRoot, getShortName, getUnits, isNamed, isPrefixed, logIndented, quit, setLinks
 
Methods inherited from class java.lang.Object
clone, equals, finalize, getClass, hashCode, notify, notifyAll, toString, wait, wait, wait
 
Methods inherited from interface org.simBio.core.Node
addDydt, addValue, getValue, setValue
 

Field Detail

Vm

public Node Vm
membrane potential (mV)


Vshift

public double Vshift
a shift of activation potential for 4 state voltage gate


Cai

public Node Cai
intracellular calcium concentration (mM)


ATP

public Node ATP
intracellular ATP concentration (mM)


gate

public Node gate
ultra-slow gate probability


pRP

public Node pRP
PR state probability for voltage-dependent gate


pAP

public Node pAP
AP state probability for voltage-dependent gate


pAI

public Node pAI
AI state probability for voltage-dependent gate


pC

public Node pC
C state probability for calcium-dependent gate


pU

public Node pU
U state probability for calcium-dependent gate


pUCa

public Node pUCa
UCa state probability for calcium-dependent gate


CaDiadic

public Node CaDiadic
local Ca2+ concentration near the mouth of L-type Ca channel (mM)


sumCa

public Node sumCa
integration of ICaL

Constructor Detail

ICaL

public ICaL()
Method Detail

prepare

protected void prepare()
Description copied from class: MembraneTransporter
construct null current

Overrides:
prepare in class MembraneTransporter
See Also:
Component.prepare()

calculate

protected void calculate(double t)
Description copied from class: MembraneTransporter
add current to Compartment.

Overrides:
calculate in class CfChannel
Parameters:
t - time
See Also:
Reactor.calculate(double)


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