org.simBio.bio.kuzumoto_et_al_2007.current.cf
Class IKs

java.lang.Object
  org.simBio.core.Component
      org.simBio.core.Parameter
          org.simBio.core.Composite
              org.simBio.core.Reactor
                  org.simBio.bio.matsuoka_et_al_2003.current.MembraneTransporter
                      org.simBio.bio.terashima_et_al_2006.current.MembraneTransporter
                          org.simBio.bio.terashima_et_al_2006.current.cf.CfChannel
                              org.simBio.bio.kuzumoto_et_al_2007.current.cf.IKs

All Implemented Interfaces:

Node

public class IKs
extends CfChannel

Delayed rectifier K⁺ current, slow component (pA). Ca²⁺ gate became a 3-state model. Phosphorylation is incorporated.

Version:

$Id: IKs.java,v 1.2 2007/12/19 06:02:24 nsarai Exp $

Author:

Masanori Kuzumoto

See Also:

Kuzumoto et al, 2007., IKs, IKs

Field Summary

Node	Ca intracellular Ca2+ concentration
Node	gate1 the open probability of voltage-dependent gate
Node	gate2 the open probability of [Ca2+]i-dependent gate
Node	gateC2 the C2 state probability of [Ca2+]i-dependent gate
Node	KCNQ1
Node	KCNQ1free
Node	KCNQ1p
Node	KCNQ1p_ratio
double	permeabilityK0
Component	Phosphorylation
Node	PKA
double	PKAtot
Node	POpen
double	relativePNa the permeability ratio of K+ and Na+
Node	Vm Membrane Potential (mV)
double	Vshift

Fields inherited from class org.simBio.bio.terashima_et_al_2006.current.cf.CfChannel

Cm, constantFieldCa, constantFieldCl, constantFieldK, constantFieldNa, permeabilityCa, permeabilityCl, permeabilityK, permeabilityNa, pOpen

Fields inherited from class org.simBio.bio.terashima_et_al_2006.current.MembraneTransporter

cCl, CCl, currentCl

Fields inherited from class org.simBio.bio.matsuoka_et_al_2003.current.MembraneTransporter

cCa, CCa, cK, CK, cNa, CNa, current, currentCa, currentK, currentNa, total

Fields inherited from class org.simBio.core.Parameter

value

Constructor Summary

IKs()

Method Summary

protected void	calculate(double t) add Cl current to Compartment.
protected void	prepare() initialization for IKs.

Methods inherited from class org.simBio.core.Composite

accept, getLink, getNode, getNodesIterator, getNodesSize

Methods inherited from class org.simBio.core.Parameter

addValue, getValue, getValueString, setInitializer, setValue, setValueString, setValueToField

Methods inherited from class org.simBio.core.Component

addDydt, end, getIndent, getIndentedShortName, getName, getName, getParent, getRoot, getShortName, getUnits, isNamed, isPrefixed, logIndented, quit, setLinks

Methods inherited from class java.lang.Object

clone, equals, finalize, getClass, hashCode, notify, notifyAll, toString, wait, wait, wait

Methods inherited from interface org.simBio.core.Node

addDydt, addValue, getValue, setValue

Field Detail

gate1

public Node gate1

the open probability of voltage-dependent gate

gate2

public Node gate2

the open probability of [Ca²⁺]_i-dependent gate

gateC2

public Node gateC2

the C2 state probability of [Ca²⁺]_i-dependent gate

Ca

public Node Ca

intracellular Ca²⁺ concentration

Vm

public Node Vm

Membrane Potential (mV)

Vshift

public double Vshift

permeabilityK0

public double permeabilityK0

relativePNa

public double relativePNa

the permeability ratio of K⁺ and Na⁺

Phosphorylation

public Component Phosphorylation

PKA

public Node PKA

PKAtot

public double PKAtot

KCNQ1

public Node KCNQ1

KCNQ1p

public Node KCNQ1p

KCNQ1free

public Node KCNQ1free

POpen

public Node POpen

KCNQ1p_ratio

public Node KCNQ1p_ratio

Constructor Detail

IKs

public IKs()

Method Detail

prepare

protected void prepare()

initialization for IKs.

Overrides:

prepare in class MembraneTransporter

See Also:

Component.prepare()

calculate

protected void calculate(double t)

Description copied from class: MembraneTransporter

add Cl current to Compartment.

Overrides:

calculate in class CfChannel

Parameters:

t - time

See Also:

CfChannel.calculate(double)