org.simBio.bio.kuzumoto_et_al_2007.current.carrier
Class INaK

java.lang.Object
  org.simBio.core.Component
      org.simBio.core.Parameter
          org.simBio.core.Composite
              org.simBio.core.Reactor
                  org.simBio.bio.matsuoka_et_al_2003.current.MembraneTransporter
                      org.simBio.bio.matsuoka_et_al_2003.current.carrier.Carrier
                          org.simBio.bio.kuzumoto_et_al_2007.current.carrier.INaK

All Implemented Interfaces:

Node

public class INaK
extends Carrier

Sodium Potassium pump current. PKA factor is incorporated into KmNai.

Version:

$Id: INaK.java,v 1.1 2007/12/15 07:21:54 nsarai Exp $

Author:

Masanori Kuzumoto

See Also:

Kuzumoto et al, 2007., Matsuoka et al, 2003, INaK

Field Summary

Node	ADP
double	amplitude0 control amplitude
double	amplitudePKAf to modulate PKA effect
Node	ATP concentration of ATP[mM]
Node	Couabain ouabain concentration
Node	dATP differential ATP [mM/msec]
double	F Faraday constant default value is 96.4867[C/mmol]
Node	Ki concentration of intracellular Potassium[mM]
double	KmATP hydrolysis coefficient of ATP
double	KmKi dissociation constant for intracellular Potassium[mM]
double	KmKo dissociation constant for extracellular Potassium[mM]
double	KmNai control dissociation constant for intracellular Sodium[mM]
double	KmNao dissociation constant for extracellular Sodium[mM]
Node	Ko concentration of extracellular Potassium[mM]
Node	Nai concentration of intracellular Sodium[mM]
Node	Nao concentration of extracellular Sodium[mM]
double	nHK Hill coefficient of Potassium
double	nHNa Hill coefficient of Sodium
Node	Pi
Node	PKA PKA phosphorylation parameter *
double	R gas constant default value is 8.3143[C*mV/K/mmol]
double	ramda relative depth of access channel
double	ratio
Node	T absolute temperature[K]
Node	Vi cell volume accessible for ion diffusion[um^3]
Node	Vm membrane potential of cell[mV]

Fields inherited from class org.simBio.bio.matsuoka_et_al_2003.current.carrier.Carrier

amplitude, Cm, E1A, E1B, E2A, E2B, gate, k1, k2, k3, k4, stoichiometryCa, stoichiometryK, stoichiometryNa

Fields inherited from class org.simBio.bio.matsuoka_et_al_2003.current.MembraneTransporter

cCa, CCa, cK, CK, cNa, CNa, current, currentCa, currentK, currentNa, total

Fields inherited from class org.simBio.core.Parameter

value

Constructor Summary

INaK()

Method Summary

protected void	calculate(double t) calculate total charge movement using reduced 2 state model 2 state gateを用いて電流を計算する
protected void	prepare() construct null current

Methods inherited from class org.simBio.core.Composite

accept, getLink, getNode, getNodesIterator, getNodesSize

Methods inherited from class org.simBio.core.Parameter

addValue, getValue, getValueString, setInitializer, setValue, setValueString, setValueToField

Methods inherited from class org.simBio.core.Component

addDydt, end, getIndent, getIndentedShortName, getName, getName, getParent, getRoot, getShortName, getUnits, isNamed, isPrefixed, logIndented, quit, setLinks

Methods inherited from class java.lang.Object

clone, equals, finalize, getClass, hashCode, notify, notifyAll, toString, wait, wait, wait

Methods inherited from interface org.simBio.core.Node

addDydt, addValue, getValue, setValue

Field Detail

Vi

public Node Vi

cell volume accessible for ion diffusion[um^3]

Ki

public Node Ki

concentration of intracellular Potassium[mM]

Ko

public Node Ko

concentration of extracellular Potassium[mM]

Nai

public Node Nai

concentration of intracellular Sodium[mM]

Nao

public Node Nao

concentration of extracellular Sodium[mM]

Vm

public Node Vm

membrane potential of cell[mV]

ATP

public Node ATP

concentration of ATP[mM]

ADP

public Node ADP

Pi

public Node Pi

R

public double R

gas constant default value is 8.3143[C*mV/K/mmol]

T

public Node T

absolute temperature[K]

F

public double F

Faraday constant default value is 96.4867[C/mmol]

KmATP

public double KmATP

hydrolysis coefficient of ATP

KmNao

public double KmNao

dissociation constant for extracellular Sodium[mM]

KmNai

public double KmNai

control dissociation constant for intracellular Sodium[mM]

KmKo

public double KmKo

dissociation constant for extracellular Potassium[mM]

KmKi

public double KmKi

dissociation constant for intracellular Potassium[mM]

nHNa

public double nHNa

Hill coefficient of Sodium

nHK

public double nHK

Hill coefficient of Potassium

ramda

public double ramda

relative depth of access channel

Couabain

public Node Couabain

ouabain concentration

amplitude0

public double amplitude0

control amplitude

PKA

public Node PKA

PKA phosphorylation parameter *

ratio

public double ratio

dATP

public Node dATP

differential ATP [mM/msec]

amplitudePKAf

public double amplitudePKAf

to modulate PKA effect

Constructor Detail

INaK

public INaK()

Method Detail

prepare

protected void prepare()

Description copied from class: MembraneTransporter

construct null current

Overrides:

prepare in class MembraneTransporter

See Also:

Component.prepare()

calculate

protected void calculate(double t)

Description copied from class: Carrier

calculate total charge movement using reduced 2 state model
2 state gateを用いて電流を計算する

Overrides:

calculate in class Carrier

Parameters:

t - time