org.simBio.bio.kuratomi_et_al_2003.current.carrier
Class Carrier

java.lang.Object
  org.simBio.core.Component
      org.simBio.core.Parameter
          org.simBio.core.Composite
              org.simBio.core.Reactor
                  org.simBio.bio.matsuoka_et_al_2003.current.MembraneTransporter
                      org.simBio.bio.kuratomi_et_al_2003.current.carrier.Carrier

All Implemented Interfaces:

Node

Direct Known Subclasses:

INaCa

public class Carrier
extends MembraneTransporter

Abstract class for ping-pong model of the carrier. Calculate Na, K, Ca ion movements using reduced 2 state model. inactivation gate is incorporated.

Version:

$Revision: 1.2 $ Created on 2003/11/24

Author:

Nobuaki Sarai

See Also:

Kuratomi S, Matsuoka S, Sarai N, Powell T, Noma A. Involvement of Ca²⁺ buffering and Na⁺/Ca²⁺ exchange in the positive staircase of contraction in guinea-pig ventricular myocytes. Pflugers Arch 446: 347-355, 2003.
Eqs (10)-(12), (23)-(25), (35)-(37) in Table 7 in Matsuoka et al, 2003

Field Summary

Node	amplitude amplitude factor (A/F)
double	Cm membrane capacitance (pF)
protected double	E1A probabilities at each state
protected double	E1B probabilities at each state
protected double	E2A probabilities at each state
protected double	E2B probabilities at each state
Node	gate reduced 2-state gate
protected double	inactive probability at inactivated state.
protected double	k1 rate constants (/ms)
protected double	k2 rate constants (/ms)
protected double	k3 rate constants (/ms)
protected double	k4 rate constants (/ms)
double	stoichiometryCa stoichiometry for Ca2+
double	stoichiometryK stoichiometry for K+
double	stoichiometryNa stoichiometry for Na+

Fields inherited from class org.simBio.bio.matsuoka_et_al_2003.current.MembraneTransporter

cCa, CCa, cK, CK, cNa, CNa, current, currentCa, currentK, currentNa, total

Fields inherited from class org.simBio.core.Parameter

value

Constructor Summary

Carrier()

Method Summary

protected void

calculate(double t) calculate total charge movement using reduced 2 state model 2 state gateを用いて電流を計算する

Methods inherited from class org.simBio.bio.matsuoka_et_al_2003.current.MembraneTransporter

prepare

Methods inherited from class org.simBio.core.Composite

accept, getLink, getNode, getNodesIterator, getNodesSize

Methods inherited from class org.simBio.core.Parameter

addValue, getValue, getValueString, setInitializer, setValue, setValueString, setValueToField

Methods inherited from class org.simBio.core.Component

addDydt, end, getIndent, getIndentedShortName, getName, getName, getParent, getRoot, getShortName, getUnits, isNamed, isPrefixed, logIndented, quit, setLinks

Methods inherited from class java.lang.Object

clone, equals, finalize, getClass, hashCode, notify, notifyAll, toString, wait, wait, wait

Methods inherited from interface org.simBio.core.Node

addDydt, addValue, getValue, setValue

Field Detail

gate

public Node gate

reduced 2-state gate

stoichiometryNa

public double stoichiometryNa

stoichiometry for Na⁺

stoichiometryK

public double stoichiometryK

stoichiometry for K⁺

stoichiometryCa

public double stoichiometryCa

stoichiometry for Ca²⁺

amplitude

public Node amplitude

amplitude factor (A/F)

Cm

public double Cm

membrane capacitance (pF)

k1

protected double k1

rate constants (/ms)

k2

protected double k2

rate constants (/ms)

k3

protected double k3

rate constants (/ms)

k4

protected double k4

rate constants (/ms)

E1A

protected double E1A

probabilities at each state

E2A

protected double E2A

probabilities at each state

E1B

protected double E1B

probabilities at each state

E2B

protected double E2B

probabilities at each state

inactive

protected double inactive

probability at inactivated state.

Constructor Detail

Carrier

public Carrier()

Method Detail

calculate

protected void calculate(double t)

calculate total charge movement using reduced 2 state model
2 state gateを用いて電流を計算する

Overrides:

calculate in class MembraneTransporter

Parameters:

t - time