org.simBio.bio.himeno_et_al_2008
Class ICaL

java.lang.Object
  org.simBio.core.Component
      org.simBio.core.Parameter
          org.simBio.core.Composite
              org.simBio.core.Reactor
                  org.simBio.bio.matsuoka_et_al_2003.current.MembraneTransporter
                      org.simBio.bio.terashima_et_al_2006.current.MembraneTransporter
                          org.simBio.bio.terashima_et_al_2006.current.cf.CfChannel
                              org.simBio.bio.himeno_et_al_2008.ICaL

All Implemented Interfaces:

Node

public class ICaL
extends CfChannel

L-type Ca channel. PKA factor is incorporated. 4 state voltage gate, from Shirokov et al. 1993, 4 state Calcium gate, from Shirokov et al. 1993, ultra-slow inactivation, ATP Dependency from Noma& Shibasaki 1985 J.Physiol,363:441-462.

Version:

$Id: ICaL.java,v 1.1 2008/02/04 02:22:25 mikaelwing Exp $

Author:

Himeno

See Also:

ICaL

Field Summary

double	amplitudePKAf to modulate PKA effect
Node	ATP intracellular ATP concentration (mM)
Node	CaDiadic local Ca2+ concentration near the mouth of L-type Ca channel (mM)
Node	Cai intracellular Ca2+ concentration (mM)
Node	gate ultra-slow gate probability
double	max
Node	pAI AI state probability for voltage-dependent gate
Node	pAP AP state probability for voltage-dependent gate
Node	pC C state probability for calcium-dependent gate
Node	PCa
Node	PCl
Node	PK
Node	PKA PKA catalitic domain I concentration
Node	PKA_fac
double	PKA0
Node	PNa
Node	pRP PR state probability for voltage-dependent gate
Node	pU U state probability for calcium-dependent gate
Node	pUCa UCa state probability for calcium-dependent gate
Node	SingleCurrentAMP to see single current amplitude
Node	Vm membrane potential (mV)
double	Vshift a shift of activation potential for 4 state voltage gate

Fields inherited from class org.simBio.bio.terashima_et_al_2006.current.cf.CfChannel

Cm, constantFieldCa, constantFieldCl, constantFieldK, constantFieldNa, permeabilityCa, permeabilityCl, permeabilityK, permeabilityNa, pOpen

Fields inherited from class org.simBio.bio.terashima_et_al_2006.current.MembraneTransporter

cCl, CCl, currentCl

Fields inherited from class org.simBio.bio.matsuoka_et_al_2003.current.MembraneTransporter

cCa, CCa, cK, CK, cNa, CNa, current, currentCa, currentK, currentNa, total

Fields inherited from class org.simBio.core.Parameter

value

Constructor Summary

ICaL()

Method Summary

protected void	calculate(double t) add Cl current to Compartment.
protected void	prepare() construct null current

Methods inherited from class org.simBio.core.Composite

accept, getLink, getNode, getNodesIterator, getNodesSize

Methods inherited from class org.simBio.core.Parameter

addValue, getValue, getValueString, setInitializer, setValue, setValueString, setValueToField

Methods inherited from class org.simBio.core.Component

addDydt, end, getIndent, getIndentedShortName, getName, getName, getParent, getRoot, getShortName, getUnits, isNamed, isPrefixed, logIndented, quit, setLinks

Methods inherited from class java.lang.Object

clone, equals, finalize, getClass, hashCode, notify, notifyAll, toString, wait, wait, wait

Methods inherited from interface org.simBio.core.Node

addDydt, addValue, getValue, setValue

Field Detail

Vm

public Node Vm

membrane potential (mV)

Vshift

public double Vshift

a shift of activation potential for 4 state voltage gate

Cai

public Node Cai

intracellular Ca²⁺ concentration (mM)

ATP

public Node ATP

intracellular ATP concentration (mM)

pRP

public Node pRP

PR state probability for voltage-dependent gate

pAP

public Node pAP

AP state probability for voltage-dependent gate

pAI

public Node pAI

AI state probability for voltage-dependent gate

pC

public Node pC

C state probability for calcium-dependent gate

pU

public Node pU

U state probability for calcium-dependent gate

pUCa

public Node pUCa

UCa state probability for calcium-dependent gate

gate

public Node gate

ultra-slow gate probability

CaDiadic

public Node CaDiadic

local Ca²⁺ concentration near the mouth of L-type Ca channel (mM)

PKA

public Node PKA

PKA catalitic domain I concentration

PKA0

public double PKA0

max

public double max

PKA_fac

public Node PKA_fac

SingleCurrentAMP

public Node SingleCurrentAMP

to see single current amplitude

PNa

public Node PNa

PK

public Node PK

PCa

public Node PCa

PCl

public Node PCl

amplitudePKAf

public double amplitudePKAf

to modulate PKA effect

Constructor Detail

ICaL

public ICaL()

Method Detail

prepare

protected void prepare()

Description copied from class: MembraneTransporter

construct null current

Overrides:

prepare in class MembraneTransporter

See Also:

Component.prepare()

calculate

protected void calculate(double t)

Description copied from class: MembraneTransporter

add Cl current to Compartment.

Overrides:

calculate in class CfChannel

Parameters:

t - time

See Also:

CfChannel.calculate(double)